Granzymes are necessary for suppressive function of regulatory T cells
نویسندگان
چکیده
منابع مشابه
Granzymes are necessary for suppressive function of regulatory T cells
Purpose Regulatory T (Treg) cells are an essential subset of CD4+ T cells that induce and maintain immunological tolerance. Preclinical animal models have demonstrated that adoptive transfer of Treg cells can prevent or cure diabetes, multiple sclerosis (EAE), inflammatory bowel disease, lupus, arthritis, and graft versus host disease. Defects in Treg cell function and number have been describe...
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Regulatory T cells (Tregs) are a subset of CD4(+) T cells that maintain immune tolerance in part by their ability to inhibit the proliferation of conventional CD4(+) T cells (Tconvs). The role of the TCR and the downstream signaling pathways required for this suppressive function of Tregs are not fully understood. To yield insight into how TCR-mediated signals influence Treg suppressive functio...
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ژورنال
عنوان ژورنال: Pediatric Rheumatology
سال: 2012
ISSN: 1546-0096
DOI: 10.1186/1546-0096-10-s1-a108